Polysaccharides are a natural and renewable reservoir which can be tailored to obtain a broad spectrum of\nmacromolecular materials. Grafting is the versatile and convenient route to develop polysaccharide based materials. In the\npresent study, an approach was made to prepare and evaluate the fast dissolving tablet of salbutamol sulphate formed by graft\ncassia seed extract polymer by direct compression method. The graft copolymerization of acrylamide on cassia was done by\nmicrowave assisted method using ceric ammonium nitrate as cross linker. The graft copolymerized cassia was characterized by\nFTIR, DSC, SEM studies and confirmed the formation of graft copolymer. Grafting was done by microwave assisted method by\nvarying the concentration of acrylamide. Maximum grafting efficiency (60%) was observed at higher concentration of\nacrylamide. The tablets were evaluated for various pharmacopoeial parameters i.e. weight variation, friability, hardness,\nthickness and diameter, disintegration test and in-vitro release. On comparative evaluation, it was observed that graft\ncopolymerized cassia showed higher disintegration while the dissolution studies revealed that more than 80% of drug was\nreleased in 15 minutes. The release rate data was fitted to various release kinetic models. It was found that formulations F0, F1 F2\nand Fm followed Korsemeyer-Peppas model, while the F3 shows anomalous transport mechanism of drug release. Therefore, it\nmay be concluded that the seed extract of cassia is a candidate as a carrier for drug delivery system. Hence it possesses the scope\nfor exploring it for further pharmaceutical application.
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